Estimated Cost of Fibrin Glue
DOI:
https://doi.org/10.55576/job.v4i2.56Keywords:
Buisness, Management, resources, cost, value, efficiencyAbstract
Objectives: The purpose of this study is to systematically investigate the current cost/mL of fibrin glue to be used in the operating room based on currently published literature.
Design: Systematic literature review.
Main outcome measurement: Cost in dollars per milliliter.
Results: Literature search produced 500 articles regarding “Fibrin Glue Cost” of which 18 had novel estimates for the cost of fibrin glue per mL. The average cost estimate for fibrin glue among the current literature is $161.61 ± $140.78. With outliers removed it was $122.45 ± $61.90.
Conclusion: Fibrin glue is used in many procedures for its hemostatic, adhesive, and sealant properties. In this literature review study, we found the average cost of fibrin glue to be $161.61/mL with indications that the true cost may be significantly cheaper. It is a financially stable option that has not become more expensive since it came into practice. Future studies are needed to investigate the overall cost benefit analysis.
Level of Evidence: IV; Systematic Review of level IV or higher evidence
Keywords: Business, management, resources, cost, value, efficiency.
References
Bouhout, S., Kam, J., Robert, M. C., et al. (2022). Cost-effectiveness analysis: fibrin glue versus sutures for conjonctival fixation during pterygion surgery. Canadian Journal of Ophthalmology, 57(1), 41-46.
Brennan M. (1991). Fibrin glue. Blood reviews, 5(4), 240–244. https://doi.org/10.1016/0268-960x(91)90015-5
Spotnitz W. D. (2014). Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive-a Laboratory and Clinical Perspective. ISRN surgery, 2014, 203943. https://doi.org/10.1155/2014/203943
Bracale U, Rovani M, Picardo A, et al. Beneficial effects of fibrin glue (Quixil) versus Lichtenstein conventional technique in inguinal hernia repair: a randomized clinical trial. Hernia. 2014 Apr;18:185-92.
Christenson JT, Kalangos A. Autologous fibrin glue reinforced by platelets in surgery of ascending aorta. The Thoracic and cardiovascular surgeon. 2004 Aug;52(04):225-9.
Wong K, Goldstraw P. Effect of fibrin glue in the reduction of post thoracotomy alveolar air leak. The Annals of thoracic surgery. 1997 Oct 1;64(4):979-81.
Machen GL, Mahmoud AM, Kleinguetl CE, et al. Vasectomy reversal utilizing fibrin glue. InBaylor University Medical Center Proceedings 2019 Apr 3 (Vol. 32, No. 2, pp. 196-198). Taylor & Francis.
Carter MJ. A Cost-benefit Analysis of Using Polyethylene Glycol Hydrogel Sealant versus Fibrin Glue as a Dural Sealant for Posterior Fossa Surgery in the United States. Journal of Health Economics and Outcomes Research. 2017 Aug 9;5(2):125-39.
Pilon F, Tosato F, Danieli D, et al. Intrasac fibrin glue injection after platinum coils placement: the efficacy of a simple intraoperative procedure in preventing type II endoleak after endovascular aneurysm repair. Interactive cardiovascular and thoracic surgery. 2010 Jul 1;11(1):78-82.
Weatherall JM, Price AE. Fibrin glue as interposition graft for tarsal coalition. Am J Orthop. 2013 Jan;42(1):26-9.
Lovisetto F, Zonta S, Rota E, et al. Use of human fibrin glue (Tissucol) versus staples for mesh fixation in laparoscopic transabdominal preperitoneal hernioplasty: a prospective, randomized study. Annals of surgery. 2007 Feb;245(2):222.
Rhemtulla IA, Tecce MG, Broach RB, et al.. Retromuscular Mesh Repair Using Fibrin Glue: Early Outcomes and Cost-effectiveness of an Evolving Technique. Plast Reconstr Surg Glob Open. 2019 Apr 11;7(4):e2184. doi: 10.1097/GOX.0000000000002184. PMID: 31321182; PMCID: PMC6554171.
Marchac, Daniel M.D.; Greensmith, Andrew L. M.D.. Early Postoperative Efficacy of Fibrin Glue in Face Lifts: A Prospective Randomized Trial. Plastic and Reconstructive Surgery 115(3):p 911-916, March 2005. | DOI: 10.1097/01.PRS.0000153219.32665.D5
Novik, B., Hagedorn, S., Mörk, UB. et al. Fibrin glue for securing the mesh in laparoscopic totally extraperitoneal inguinal hernia repair. Surg Endosc 20, 462–467 (2006). https://doi.org/10.1007/s00464-005-0391-3
Ferrarese, Alessia, Bindi, Marco, Rivelli, Matteo, et al. "Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients" Open Medicine, vol. 11, no. 1, 2016, pp. 497-508. https://doi.org/10.1515/med-2016-0087
Delhi J Ophthalmol 2019;29;35-38; Doi http://dx.doi.org/10.7869/djo.439
Ramachandran R, Gunasekharan V, Pillai AV, et al. Fibrin glue versus autologous platelet-rich fibrin - comparison of effectiveness on the cohort of patients with fistula-in-ano undergoing video-assisted anal fistula treatment. J Minim Access Surg. 2022 Jul-Sep;18(3):443-449. doi: 10.4103/jmas.jmas_297_21. PMID: 35708389; PMCID: PMC9306109.
Johnson L, Cusick TE, Helmer SD, et al. Influence of fibrin glue on seroma formation after breast surgery. The American journal of surgery. 2005 Mar 1;189(3):319-23.
Daneshrad P, Chin GY, Rice DH. Fibrin glue prevents complications of septal surgery: findings in a series of 100 patients. Ear, nose & throat journal. 2003 Mar;82(3):196-7.
Khalid AQ. Initial experience with hemostatic fibrin glue as adjuvant during drainless parotidectomy. The Saudi dental journal. 2011 Apr 1;23(2):67-71.
Reiner AP. Fibrin glue increasingly popular for topical surgical hemostasis. Laboratory Medicine. 1999 Mar 1;30(3):189-93.
Associated Press. FDA Approves Nation's First Commercial Surgical Glue. Los Angeles Times; 1998.
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